Microbiome Devote themselves to environmental sustainability
One of the most revolutionary advances in the biological sciences in recent years has been the realization that microbial communities occupy virtually every environment and have central roles in human health and disease, as well as in the biogeochemical processes that sustain life on our planet.
Microbial EVs Determine our health
Humans are holobionts; of the DNA in humans, 1% is derived from the human genome, and 99% is derived from microbial genomes (the microbiome). Extracellular vesicles (EVs) are lipid bilayer-delimited nanoparticles and key messengers in cell-to-cell communication. Microbial EVs are both positively and negatively involved in the pathogenesis of various intractable diseases, including immune, metabolic, and nervous diseases, and cancers.
Medicine Delivery through microbiome
and EV convergence
Microbial EVs are commensal nonliving materials that act on the human immune, metabolic, and nervous systems to induce protective responses. Furthermore, microbial EVs have a unique ability to target distant organs and effectively penetrate cellular organelles which are undruggable targets. Microbial EV therapies are new modality and first-in-class drugs to treat intractable diseases with high unmet need.