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Probiotic nanovesicles reduce intestinal inflammatory response in vivo

관리자 2020-08-04 09:50:03 Hit 1,291

 In collaboration with Ehwa Women's University, MD Healthcare published our findings on the intestinal anti-inflammatory effect of extracellular vesicles (EVs) derived from Lactobacillus paracasei in Nature Experimental & Molecular Medicine (May 2020). 

Editorial Summary

Inflammatory bowel disease: Vesicles from gut bacteria quell inflammation

Tiny vesicles released by a bacterial species found in the human gut can reduce symptoms of inflammatory bowel disease (IBD) and prevent disease progression. People with IBD have a decreased abundance of Lactobacilli bacteria in their gut, creating an imbalance that perpetuates the disease. Replenishment of this bacteria may become a valuable therapy. Chang Mo Moon at Ewha Womans University, Yoon-Keun Kim at MD Healthcare, both in Seoul, South Korea, and co-workers demonstrated how extracellular vesicles (EVs) released by Lactobacilli paracasei can actively prevent bowel inflammation. These EVs contain a mixture of proteins, nucleic acids and other biomolecules. The team administered EV to cultured human colorectal cancer cells and to mice with induced colitis. The EVs decreased pro-inflammatory protein activity and boosted levels of protective cellular membrane proteins via augmenting ER stress pathway.


<Image: Proposed model of L. paracasei-induced ER stress against LPS-induced inflammation in HT29 human colorectal cells.>